Mahetab Patel, Dr. Jitendra Patel, Dr. Umesh Upadhyay
Drugs can be delivered using Ethosomes, which are non-invasive delivery systems, to deep skin layers and/or the systemic circulation. Though conceptually complex, ethosomal systems are distinguished by their ease of preparation, safety, and effectiveness a combination that can greatly increase their utility. Ethosomes are flexible, squishy vesicles designed for better active drug distribution. This page discusses research done using several ethosomal systems and a wide variety of medications using in vitro, in vivo, animal models, and human subjects. Ethosomes' special structure allows them to enclose and transmit through the skin highly lipophilic substances like propranolol and trihexyphenidil as well as cationic medicines like testosterone and minoxidil. The treatment with the ethosomal acyclovir formulation significantly improved all the examined parameters, according to the findings of a double-blind, two-armed, randomised clinical investigation. It was discovered during preliminary research with insulin and plasmids that the ethosomal carrier may be used to improve the delivery of these medicines. In subsequent research, the ethosomal technique was expanded to allow the introduction of chemicals into microbes and cultivated cells. The research and future development of novel, improved therapeutics are faced with a number of obstacles and opportunities due to the enhanced delivery of bioactive chemicals via the skin and cellular membranes via an ethosomal carrier.
KeywordsEthosomes; transdermal; vesicular carriers; ethanol; phospholipid
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