जर्नल ऑफ़ न्यूरोलॉजी एंड न्यूरोसाइंस

• जर्नल होम
• पुरालेख
लेखक
• लेखक दिशानिर्देश
• पांडुलिपि जमा करें
विस्तार से
• उद्देश्य और दायरा
• प्रकाशन नैतिकता
• समकक्ष समीक्षा प्रक्रिया
• कॉपीराइट
• संपर्क करें

अमूर्त

ISAAC syndrome

Sumeet Swapan Roy* , Raghav Kapoor, Rahul Saini and Nikita Goel

ISSAC Syndrome is a form of peripheral nerve hyperexcitability caused by continuous muscle fiber activity. The patient usually presents with the complaints of twitching and stiffness. Symptoms such as myokymia and muscle spasm, may persist during sleep. The patients are reported to be CASPR2 antibody positive which is ought to be the pathogenic antibody in ISSAC Syndrome. The patients are commonly treated with immunomodulatory therapies which includes steroids, plasma exchange therapy and rituximab for nonresponsive cases. Treatment also includes symptomatic management which has no effect on disease progression.