Atousa Janzadeh
Objectives: Spinal cord injury (SCI) causes motor deficits, urinary incontinence and neuropathic pain. This study has been accomplished to provide a protocol for photobiomodulation therapy (PBMT) to gain a significant reduction in complications of the SCI. To date, it has not yet been determined whether a more prominent effect would be achieved by increasing the number of days of irradiation or daily dose of PBMT.
Methods: The study was performed in two steps. In the first step, comparison between the effects of PBMT (90sec), separately for two and four weeks on pain, and also improvement of movement (BBB score) was made. In the second step, the comparison to evaluate the effects of different durations of radiation (27, 45, 90 and 117 seconds) was done. Also, Oxidative stress and fibroblast invasion and time to gain spontaneous of urination were assessed in the both steps.
Results: Healing process in movement and pain stopped with discontinuation of radiation on week2 and fibroblast invasion resumed, on the other hand, no improvement was seen in the group receiving PBMT for 27 seconds compared to the ones receiving higher durations of laser radiation as the process of discernible improvement of movement and pain, so, that animals receiving 117s PBM have a higher BBB score even in the first 3days.
Conclusion: Number of radiation days is an important factor in improving the mobility; however, the daily dose of radiation is more essential in pain relief
KeywordsPhotobiomodulation therapy; Spinal cord injury; Motor function recovery; Hyperalgesia; GPX; SOD; MDA
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